BONE GRAFTING TECHNOLOGY

The Indian Institute of Technology Kanpur (IIT-K) has joined hands with Canada-based biotechnology company Conlis Global Inc. to license an innovative new technology that promotes bone healing and regeneration.

What is Nano Hydroxyapatite-based Porous Composite Scaffolds?

1. About:

   1. Nano-hydroxyapatite (nHAp) composite scaffolds are biodegradable and possess osteoinductive and osteopromotive properties, making them suitable for bone regeneration applications.

1. Osteoinductive properties are properties that promote the creation of new bone,
2. Osteopromotive properties enhance osteoinduction without having osteoinductive properties.
   2. The scaffolds exhibit excellent biocompatibility, facilitating favorable cell-material interactions with osteoblast cells. Furthermore, they exhibit high mechanical strength, which results from the strong interaction between the polymer network and the solvent.

2. Characteristics:

   1. Having osteoinductive and osteopromotive properties, this material exhibits bone healing and growth characteristics.
   2. The high biocompatibility of these materials enables effective cell-material interactions with osteoblast cells, resulting in significant mechanical strength and seamless integration between the polymer network and the solvent.
      1. Osteoblast cells are responsible for bone mineralization during bone formation and bone remodeling.

3. Applications:

   1. Calcium phosphate is widely used in the medical field, especially in orthopedic and dental implants, bone graft substitutes, coatings for prosthetic devices, and scaffolds for tissue engineering.
   2. Functional scaffolds, when used as fillers in large-sized bone defects, maintain connectivity and structural integrity, providing comfort without compromising oxygenation and blood circulation.
   3. Calcium phosphate enhances tissue formation, mineralization, and accelerates defect healing.

What is Bone Grafting?

1. About:

   1. Bone grafting is a surgical technique that involves using transplanted bone to repair and reconstruct diseased or injured bones.
   2. This method can be used to repair bones anywhere in the body.
   3. To obtain bone for grafting, surgeons can obtain it from a variety of sources, including hips, legs, and ribs.

2. Objective:

   1. The primary objective of the invention is to overcome the shortcomings of existing treatments.
      • Other options are associated with infection and immune-related complications.
   2. This technology provides delivery of active molecules, antibiotics or any other drug into the bone to deal with bone decay, reconstruction of irregular bone defects and dental applications.

3. Functions:

   1. The material allows the bone to regenerate in a natural way by carrying bone-active biomolecules and placing them directly on the site where the implant is placed.
   2. This material can be used to repair and reconstruct bone problems while avoiding the problems and difficulties of the technologies in the market today.
   3. Functional scaffolds can be used to fill large bone defects without harming oxygen and blood flow, which helps tissue growth, mineralization and faster defect healing.
   4. It can also be used in place of bone implants, which has limitations.

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